The role of microsatellite instability testing in management of colorectal cancer.
نویسنده
چکیده
FS MSI refers to an accumulation of errors within microsatellite regions of DNA that lead to hypermutation and are caused by a deficient DNA mismatch repair system. The mismatch repair system serves an editing function— similar to a spellcheck mechanism—that identifies errors and removes them from the DNA. When this repair system is faulty, microsatellites in the DNA develop short nucleotide repeats that lead to frame-shift mutations.
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ورودعنوان ژورنال:
- Clinical advances in hematology & oncology : H&O
دوره 14 7 شماره
صفحات -
تاریخ انتشار 2016